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The Magic Plant Extracts are Endless Natural Medicine Treasures
Jul 31, 2018

As we all know, paclitaxel is an active ingredient and has good biological safety. Because of its effective antiproliferative properties, it has been widely used in the treatment of cancer and arterial diseases. Paclitaxel is currently only approved for drug-eluting stents in cardiovascular applications. Paclitaxel is a white crystalline powder with a chemical formula of C47H51NO14 and a molecular weight of 853.9 Dalton. Paclitaxel is highly lipophilic and insoluble in water, and its melting temperature is 216-217 degrees.

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Taxol, very unique in chemical properties, is highly hydrophobic and can enter the intima of the artery. Even after a brief exposure, the effect of stimulating cells is still long, which makes paclitaxel an ideal local drug delivery system. In small-scale animal and clinical studies, the local delivery of paclitaxel by injecting catheter, balloon catheter and coated balloon shows good effect and good biological safety. As for the long-term efficacy and safety of the treatment, further pre clinical and clinical studies are needed.


Resveratrol can inhibit obesity induced by high fat diet, so it is a good natural food for human to prevent obesity. Not only that, resveratrol also has anti-cancer, anti-oxidation, anti-inflammatory, antibacterial effects of people's favorite. Resveratrol can release bad cholesterol and effectively suppress the prevention and treatment of high fat to a certain extent.


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Resveratrol glucuronide has the function of lowering the activity of cholesterol, and its specific mechanism is to reduce the cholesterol pathway through the bile acid metabolism pathway by resveratrol and resveratrol glucuronide. Data showed that resveratrol and resveratrol glucuronide could reduce the overall cholesterol content and lipid accumulation in cells. Resveratrol not only increases the synthesis and excretion of bile acids, but also reduces the synthesis of cholesterol and the increase of the cholesterol efflux. From the expression level of related genes, resveratrol and resveratrol have the potential to reduce the cholesterol level of the liver. In addition, the potential of resveratrol and resveratrol is likely to be more valuable than resveratrol because of low toxicity of resveratrol glucuronide.


Garlic has been used worldwide not only as a flavoring agent, but also as a drug and widely eaten from ancient times to today. Garlic and derived compounds derived from garlic proved to be of medical value. The main active component of garlic is S-allylcysteine sulfoxide (S-allylcysteine sulfoxide), commonly known as allicin. It is an organic sulfur compound composed of allyl, sulfoxide and amino acid cysteine.

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Cardiovascular diseases have become the number one killer in many parts of the world. In a new study, the effects of S-allylcysteine sulfoxide on preventing myocardial infarction were evaluated using isoproterenol-induced myocardial infarction models. The results of the new study found that the accumulation of lipid in rats induced by isoproterenol could be reversed by S- allyl cysteine sulfoxide, that is to say, the lipid accumulation in the model was reduced after S- allyl cysteine sulfoxide preconditioning. This may be due to the antioxidant effect of S- allyl cysteine sulfoxide. S- allyl cysteine sulfoxide can direct free radical scavenging, and can reduce lipid accumulation indirectly by reducing or inhibiting lipid peroxidation, which is of great value in clinical application.


Rosemary is an aromatic evergreen shrub plant, located in the Mediterranean, South America and other regions, is reported to have anti-diabetic properties. In the study in vivo, rosemary extracts can reduce the plasma glucose levels in the animal models of insulin resistance and insulin resistance induced by streptozotocin and four oxouracil, as well as in diet, high fat diet induced obesity and insulin resistance.

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A study by the Brock University in Canada revealed that the concentration of polyphenols in rosemary extracts has a mechanism that increases the activation of adenosine nucleotides (AMP) activated kinase in muscle cell glucose uptake. These mechanisms suggest that polyphenols may be responsible for the anti hyperglycemic properties of rosemary extract in the body. . Therefore, polyphenol oxalic acid has certain potential value in the prevention and management of insulin.

  

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Schisandra chinensis, as a famous traditional Chinese medicine, has a long history. It is a widely used and large amount of Chinese medicinal herbs. It is the first choice for the production of brain, nerves, neurodrugs and health care products. It is an economic crop and Chinese herbal medicine with high value and broad prospects for development. The root and leaf of Fructus schisandrae chinensis has been used to treat senile dementia in some prescriptions. A new study assessed the inhibitory effect of Schisandra chinensis root and leaf extracts on Alzheimer's disease-related enzymes, showing some positive results.


The most common drug in the treatment of Alzheimer's disease is cholinesterase inhibitors blocking acetylcholine. The extract of Schisandra chinensis Leaves shows antioxidant stress and dose dependent inhibitory effect on acetylcholinesterase and butylyl cholinesterase, which may have potential for the treatment of Alzheimer's disease.


The water extract of Schisandra chinensis cotyledon is rich in phenolic compounds, and shows strong antioxidant neuroprotective effect and anti-cholinesterase activity. The mechanism of Fructus Schisandrae leaf extract exerts its neuroprotective properties by inhibiting the activity of cholinesterase and preventing neurodegeneration induced by oxidative stress. It has a certain potential for the application of Chinese herbal medicine.


Source: CPHI pharmaceutical Online


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